The afternoon crash follows two closures of the highway this morning in the Lehigh Valley.
Traffic is backed up this afternoon on Route 22 East in the area of the Route 378/Schoenersville Road interchange following a multi-vehicle crash.
The good news is the multi-vehicle crash, reported about 3:55 p.m. on Route 22 East at Route 378/Schoenersville Road in Bethlehem, was cleared about 4:30 p.m., PennDOT says.
Details on the crash were not immediately available.
It follows the closure of Route 22 West this morning following a four-vehicle crash that left one person dead and two critically injured and a brief closure of Route 22 East, also this morning, due to a tractor-trailer crash on the Lehigh River bridge. Both of those incidents were in Whitehall Township.